IMMUNOHISTOCHEMICAL STUDY ON PROSTATIC ACID PHOSPHATASE
نویسندگان
چکیده
منابع مشابه
Prostatic Acid Phosphatase: A Potpourri*
In 1938, Gutman et al. (6) described increased levels of acid phosphatase in metastatic carcinoma of the prostate. Since then, when most of us hear the term "acid phosphatase" we immediately think of prostatic cancer, and justifiably so. The link, however, between the test and the diagnosis is not as clear and simple as many of us would like to believe. I would first like to discuss this enzyme...
متن کاملProstatic acid phosphatase in serum of patients with prostatic cancer is a specific phosphotyrosine acid phosphatase.
We developed an assay to measure at acid pH the phosphotyrosine phosphatase activity in sera from patients with prostatic cancer. The method used quantifies the inorganic phosphate liberated from phosphotyrosine after incubation with serum, followed by the deproteinization of the reaction mixture. A high acid phosphatase (EC 3.1.3.2) activity towards phosphotyrosine was observed in all sera fro...
متن کاملImmunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands.
Periurethral glands were found in 7 of 10 female urethras harvested at autopsy. In all 7 cases, immunoperoxidase staining showed the presence of prostatic acid phosphatase in glandular acini. By similar techniques, prostate specific antigen was demonstrated in acini of 4 of 7 urethras with periurethral glands. The findings support a female homologue of the male prostate.
متن کاملBiochemical properties of human prostatic acid phosphatase.
The electrophoretic pattern (in polyacrylamide gel) for acid phosphatases in the prostate gland was compared with that for other tissues. lsoenzyme 2 predominates in the prostate. The isoenzyme was isolated from the prostate and its biochemical properties were compared with those of acid phosphatases isolated from spleen. lsoenzyme 2 has a molecular weight of about 100,000. Its optimum pH is be...
متن کاملEmerging Roles of Human Prostatic Acid Phosphatase
Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is diagnosed in its early stages, there is a higher probability that it will be completely cured. Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells and its le...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1983
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1928.74.4_514